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RECENT PUBLICATIONS
Being Updated - June 2003
Cancer Related:
An Update on milk components with anticancer potential. ( Parodi, P. W. (2002) Milk components with anticancer potential. Proceedings
of the Nutrition and Health Conference - Bulletin-of-the-International-Dairy-Federation.
2002, No.375, 97-102)
Abstract: Milk contains a number of components with anticancer potential.
The fat phase contains conjugated linoleic acid (CLA), which is a potent inhibitor of
mammary tumorigenesis. Sphingomyelin and other sphingolipids protected against colon tumour development
in mice. Butyric acid can inhibit mammary tumour occurrence in rats, while 13-methyltetradecanoic acid suppressed cell growth
in a number of human cancer cell lines and inhibited the growth of human prostate and liver cancer cells implanted in mice.
Milk lipids also contain the common anticancer agents b-carotene and vitamin A. Milk protein, particularly whey protein, has
potent antitumour action in animal models of colon and mammarytumorigenesis and is superior to other proteins such as beef and
soy. Lactoferrin inhibited tumour development in rodent colon, lung, oesophagus, bladder and tongue. Lactoferrin can also
inhibit angiogenesis and prevent metastases. Milk is a rich source of calcium. A large number of animal studies and human
epidemiological and intervention studies suggest calcium can help prevent colon adenoma and carcinoma.
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Griffiths CEM, Cmberbatch M, Tucker SC, Dearman RJ,
Andrew S, Headon DR & Kimber I (2001) Exoxenous topical lactogerrin
inhibits alleergen-induce Langerhams cell migration and cutaneous
inflammnatin in hummans. British
Journal of Dermatology 144 (4):715-725.
Abstract:
Topical exposure to LF 2 h prior to sensitization caused a significant
reduction in contact allergen (diphenylcyclopropenone, DPC)-induced LC
migration from the epidermis as judged by the altered frequency of cells
expressing either HLA-DR or CD1a determinants. That this reduction was
secondary to an inhibition of TNF-α production was indicated by the
fact that LF failed to influence LC migration induced by intradermal
injection of this cytokine. In approximately 50% of those volunteers who
displayed local inflammation in response to DPC, LF was found to cause a
discernible reduction in the clinical severity of the reaction, associated
with reduced infiltration of inflammatory cells. These data demonstrate that
LF is able to influence cutaneous immune and inflammatory responses,
possibly because of an impaired production of local proinflammatory
cytokines.
Conjugated linoleic acid and C10 and C12 fatty acids in milk fat
may enhance calcium absorption in vivo: (Jewell, C.
& Cashman, K.D. (2003) The effect of conjugated linoleic acid and shot
chain fatty acids on trasnepithelian calcium transport in human instenstine
like Caco-2 cells. British Journal of Nurition 89(5):639-647.
Capric (10:0) and lauric (12:0)
acid and conjugated linoleic acid (CLA) have been shown to increase
paracellular permeability across human intestinal-like Caco-2 cell
monolayers. While this has generated interest in terms of improved drug
absorption and delivery, little has been done in terms of their potential
effect on nutrient transport across the intestinal epithelium. Therefore,
the objective of the present study was to investigate the effect of these
fatty acids on transepithelial Ca transport in Caco-2 cells. Cells were
seeded onto permeable transport membranes and allowed to differentiate, over
21 d, into intestinal-like cell monolayers. Monolayers (n 9 per
treatment) were exposed to 0 (control) or 80 μM-10:0, 80 μM-12:0,
80 μM-18:2, 80 μM-CLA (mixed isomers), 80 μM-cis-9,trans-11
CLA or 80 μM-trans-10,cis-12 CLA for 22 d after seeding
(chronic effect) or for 24 h before Ca transport studies (acute effect) on
day 22. After exposure, transepithelial and transcellular transport of 45Ca,
fluorescein transport (a marker of paracellular Ca transport) and
transepithelial electrical resistance (TEER, an indicator of permeability)
were measured. Overall Ca transport and TEER in Caco-2 cells were unaffected
by exposure to any of the fatty acids for 24 h, or to 18:2, CLA blend or cis-9,trans-11
CLA for 22 d. Paracellular (but not total transepithelial and transcellular)
Ca transport across Caco-2 cells was significantly increased (P<0·01,
by about 1·5-fold relative to the control value) by exposure to 10:0, 12:0
and trans-10,cis-12 CLA for 22 d, suggesting that these non-esterified
fatty acids could potentially enhance Ca absorption in vivo.
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