PROBIOTICS

For information on the current status of probiotics, visit:       http://www.usprobiotics.org/101/

The following introduction to probiotics has been taken from the Probiotic Web Page (cited above) and from a  2000 IFTpresentation by Dr. T. R. Klaenhammer.

Dairy foods fermented by lactic acid bacteria have long been held in special favor as safe and nutritious foods that may also elicit positive effects on health and well being.  There is increasing evidence the live lactic acid bacteria in these products do indeed have health benefits.  Select members of the lactic acid bacteria have now been implicated through clinical studies to provide resistance to enteric pathogens, stimulate the immune system, and help maintain a balanced gastrointestinal micro flora.

The term "Probiotic" has been given many meanings, but it now generally recognized as a fermented dairy product containing live lactic acid bacteria that have been specially selected to provide specific health benefits. Most probiotic products contain bacteria from the genera Lactobacillus or Bifidobacterium.  Probiotic  products should be safe, effective, and should maintain their effectiveness and potency until they are consumed. 

Reported functions of probiotics as a part of a healthy diet have included:
      -providing support to the immune system
      -maintain a healthy gut flora to provide increased resistance to disease
      -reduce lactose intolerance
      -may assist in preventing some cancers
      -may reduce cholesterol for some individuals

Why the interest in probiotics? For centuries folklore has suggested that  fermented dairy products containing probiotic cultures are healthful. Recent controlled scientific investigation has supported some of these traditional views, suggesting the value of probiotics as part of a healthy diet. In addition, the emergence of some new public health risks suggest an important role for effective probiotics. The ability of probiotic bacteria to support the immune system could be important to the elderly or other people with compromised immune function. Ask your doctor before taking any dietary supplement. Some infections, once thought self-limiting or readily treatable with antibiotics, are now recognized as more serious health threats. Prevention of infections before they occur is clearly the better alternative. Vaginitis used to be considered just an annoyance. Now we know it is associated with low birth weight and increased risk of sexually transmitted diseases. New foodborne pathogens have emerged as prevalent and life threatening, including Shiga-like Escherichia coli strains. Multiple antibiotic resistances are a continual threat in the battle against once-treatable infections. And in non-industrialized nations, infections such as rotavirus, claim the lives of hundreds of thousands of infants yearly. Probiotics may be the avenue to provide a safe, cost-effective, "natural" approach that adds a barrier against microbial infection.  

"Dairy foods fermented by lactic acid bacteria have long been held in special favor as safe and nutritious foods that may also elicit positive effects on health and well being. Archaic texts from Irac dating back to 3200 BC hold references to cheese, butter, and yoghurt indicating that fermented dairy foods have long been part of the daily human diet. Soured milk bore the first pure bacterial culture (Bacterium lactis, Lister 1873) and later the probiotic concept. Eli Metchnikoff (1904) attributed the long and healthy lifestyle of Bulgarian peasants to the consumption of fermented milks. Over the last 30 years, intensified efforts to identify and characterize lactic acid bacteria have revealed their many critical roles in dairy foods, including: acid production, texture development, flavor generation, preservation, and synthesis of B-vitamins. Select members of the lactic acid bacteria have now been implicated through clinical studies to provide resistance to enteric pathogens, stimulate the immune system, and help maintain a balanced gastrointestinal microflora. Advances in microbiology, molecular biology and genomics, focused on dairy lactic acid bacteria, have begun to elucidate their roles and interactions within complex fermentation ecosystems and the gastrointestinal tract. Genetic technologies can further be exploited to expand upon the beneficial activities of lactic acid bacteria through metabolic engineering and/or expression of novel products, such as digestive enzymes, vaccines, or other bioactive compounds. The future linkage of lactic acid bacteria and health holds considerable promise as a result of their long and safe consumption through dairy foods, and their potential to deliver novel bioactive molecules that positively impact human health and well being."

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An IFT expert panel on food safety and nutritional has evaluated health-promoting effects attributed to probiotics (Sanders, M. E. 1999 Food Technol. 53(11):67-77)

Probiotics may have potential roles of probiotics as natural barriers to pathogens associated with intestinal disease), Possible effects on on human health include alleviation of symptoms of lactose intolerance, anti-diarrheal effects, reduced risks of some cancers, improved intestinal and urogenital health, enhanced immune functioning, moderation of allergic reactions, inhibition of Helicobacter pylori stomach infections, possible cholesterol-lowering effects, mild anti-hypertensive effects, effects on alcohol-induced liver disease)
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Mc Intosh et al. (Nutrition Research 21(7):1053-1066) support the view that "combinations of foods, such as dairy foods with cereals and/or probiotic bacteria provide potentially interesting alliances in reducing the risk of colon cancer". 

LINKS:

bulletDairy Management Inc.
bulletEuropean Feed and Food Cultures Association
bulletFDA - Center for Food Safety and Applied Nutrition
bulletProbiotics reports at the Food and Agriculture Organization of the United Nations (FAO)
bulletInternational Scientific Association for Probiotics & Prebiotics
bulletCanadian Research and Development Centre for Probiotics
bullet

Syndifrais (French) Syndifrais is an association of French manufacturers of fresh dairy products including yoghurts, fermented milks, "fromages frais", fresh dairy desserts and creams. Within the association, the Scientific Committee of Syndifrais investigates the nutritional value and benefits of yoghurt as well as other fresh dairy products. This Committee gathers research from the public and private sectors and is currently chaired by Professor Jean-Louis Bresson, from Necker Hospital, Paris. Several studies conducted have already resulted in recognition by the scientific community of the positive effect of regular consumption of yoghurt, due to the action of live cultures. Syndifrais regularly publishes a "Scientific Letter” (around 5 issues per year ) which contain recent scientific articles on lactic acid bacteria/health effects with short analyses and comments. Examples of the Scientific Letters:
bullet

Scientific Letter 4
Scientific Letter 5

Scientific Letter 6

Scientific Letter 7

Scientific Letter 8

Scientific Letter 9

Scientific Letter 10

Scientific Letter 12

bulletNational Dairy Council Publishes: Functional Foods: An Overview Probiotics, Prebiotics, and Synbiotics

PROBIOTIC PRODUCTS - LINKS

http://www.phototour.minneapolis.mn.us/candida/summary.html
http://www.premierpet.com/probiotic.html
(equine)
http://www.valio.fi/lgg/leading.html
(Lactobacillus GG)
http://www.elixa.com/nutrient/colonizer.htm
(animal health) http://www.naturalconnections.com/cgi-local/SoftCart.exe/MultiPro.htm?E+scstore
http://www.horizonpress.com/gateway/probiotic.html

http://www.equishine.com/Supplements/Probiotic/probiotic.html
(animal health)
http://www.live-well.com/

http://www.kefir.com/

http://www.kefir.com/prods.htm

http://www.actimelusa.com/

http://www.biogaia.com

References of interest in respect to Probiotics

2003

2002:

2001:

Lourens-Hattingh, A & Violen,B C (2001) Yogurt as probiotic carrier food. International Dairy Journal Volume: 11(1-2):1-17

McNaught C E & Mc Fie (2001) Probitocs in clinical Practice. Nutrition Research Volume: 21(1-2): 343-353

Prior to 2001

Buttriss-J 1997 Nutritional properties of fermented milk products. International-Journal-of-Dairy-Technology; 50 (1) 21-27

Bezkorovainy-A; Kot-E 1998 Interaction of bifidobacteria with ferric iron.International-Dairy-Journal; 8 (5/6) 507-512

Campbell-CG; Luedecke-LO; Schultz-TD 1999 Yogurt consumption and estrogen metabolism in healthy premenopausal women. Nutrition-Research; 19 (4) 531-543

Campbell-CG 1998 Influence of yogurt consumption on immune function and estrogen metabolism in premenopausal women. Dissertation-Abstracts-International,-B; 58 (8) 4151 Order no. DA9806714, 114pp.

Chandan-RC 1999 Enhancing market value of milk by adding cultures. Journal-of-Dairy-Science; 82 (10) 2245-2256.

Desobry-Banon-S; Vetier-N; Hardy-J 1999 Health benefits of yogurt consumption. A review. International-Journal-of-Food-Properties; 2 (1) 1-12.

Fooks-LJ; Fuller-R; Gibson-GR 1999 International-Dairy-Journal; 9 (1, Recombinant dairy starters, probiotics, and prebiotics: scientific, technological, and regulatory challenges) 53-61

Ganjam-LS; Thornton-WH Jr; MacDonald-RS 1996 Yogurt peptides, bovine less than alpha greater than -lactalbumin and less than beta greater than -casein alter cell proliferation in IEC-6 and Caco-2 intestinal cells. 1996 IFT annual meeting: book of abstracts, p. 150 ISSN 1082-1236

Ganjam-LS; Thornton-WH Jr; Marshall-RT; MacDonald-RS 1997 Antiproliferative effects of yogurt fractions obtained by membrane dialysis on cultured mammalian intestinal cells. Journal-of-Dairy-Science; 80 (10) 2325-2329

Gurr-MI 1991 Health benefits of cultured and culture-containing milks.BNF-Nutrition-Bulletin; 16 (2) 73-82

Kasper-H 1998 Protection against gastrointestinal diseases - present facts and future developments.  International-Journal-of-Food-Microbiology; 41 (2) 127-131

Kulkarni-N; Reddy-BS 1994  Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proceedings-of-the-Society-for-Experimental-Biology-and-Medicine; 207 (3) 278-283

Loo-J-van; Cummings-J; Delzenne-N; Englyst-H; Franck-A; Hopkins-M; Kok-N; Macfarlane-G; Newton-D; Quigley-M; Roberfroid-M; Vliet-T-van; Heuvel-E-van-den 1999 Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project. British-Journal-of-Nutrition; 81 (2) 121-132.

Marteau-P; Pochart-P; Bouhnik-Y; Rambaud-JC 1994 [Fate and effects of Lactobacillus acidophilus and bifidobacteria from fermented milks in the human gut.] Cahiers-de-Nutrition-et-de-Dietetique; 29 (6) 336-340.

Parodi-PW 1999 The role of intestinal bacteria in the causation and prevention of cancer: modulation by diet and probiotics. Australian-Journal-of-Dairy-Technology; 54 (2) 103-121

Parodi-PW 1999 The role of intestinal bacteria in the causation and prevention of cancer: modulation by diet and probiotics. Australian-Journal-of-Dairy-Technology; 54 (2) 103-121

Pool-Zobel-BL; Watzl-B 1994 [Antigenotoxic and anticarcinogenic constituents in foods.] Antigenotoxische and antikanzerogene Inhaltsstoffe in Lebensmitteln. Verbraucherdienst-; 39 (1) 3-11

Sanders-ME 1993 Summary of conclusions from a consensus panel of experts on health attributes of lactic cultures: significance to fluid milk products containing cultures. Journal-of-Dairy-Science; 76 (7) 1819-1828

Schwab-CE; Huber-WW; Parzefall-W; Hietsch-G; Kassie-F; Schulte-Hermann-R; Knasmueller-S    2000 Search for compounds that inhibit the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Critical-Reviews-in-Toxicology; 30 (1) 1-69

Strand-M; Babus-V 1997 Anticarcinogenic activity of fermented dairy products.   Mljekarstvo-; 47 (3) 201-207

Wigertz-K; Svensson-UK; Jagerstad-M 1997 Folate and folate-binding protein content in dairy products  Journal-of-Dairy-Research; 64 (2) 239-252.

Wigertz-K; Svensson-UK; Jagerstad-M 1997 Folate and folate-binding protein content in dairy products  Journal-of-Dairy-Research; 64 (2) 239-252.

Ganjam-LS; Thornton-WH Jr; MacDonald-RS 1996 Yogurt peptides, bovine less than alpha greater than -lactalbumin and less than beta greater than -casein alter cell proliferation in IEC-6 and Caco-2 intestinal cells. 1996 IFT annual meeting: book of abstracts, p. 150 ISSN 1082-123

Marteau-P; Pochart-P; Bouhnik-Y; Rambaud-JC 1994 [Fate and effects of Lactobacillus acidophilus and bifidobacteria from fermented milks in the human gut.] Cahiers-de-Nutrition-et-de-Dietetique; 29 (6) 336-340.

Pool-Zobel-BL; Watzl-B 1994 [Antigenotoxic and anticarcinogenic constituents in foods.] Antigenotoxische and antikanzerogene Inhaltsstoffe in Lebensmitteln. Verbraucherdienst-; 39 (1) 3-11

Kulkarni-N; Reddy-BS 1994  Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase. Proceedings-of-the-Society-for-Experimental-Biology-and-Medicine; 207 (3) 278-283

Sanders-ME 1993 Summary of conclusions from a consensus panel of experts on health attributes of lactic cultures: significance to fluid milk products containing cultures. Journal-of-Dairy-Science; 76 (7) 1819-1828

Gurr-MI 1991 Health benefits of cultured and culture-containing milks.BNF-Nutrition-Bulletin; 16 (2) 73-82

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